Profil Metabolik Jalur Glikogenolisis Puyuh dalam Kondisi Stres Panas dengan Pemberian Diallyl n-Sulfida (Dn-S) Organik

Andi Mushawwir, Nono Suwarno, Diding Latipudin


The heat stress plays an important role for reducing feed utilization, blood profile, growth performance, and its influence performance and economic loss. Supplemented of diallyl n-sulfide of garlic is one the efforts to avoid the negative impact of heat stress. One hundred anh twenty five of female quails, 11 weeks of age, were used ini this study to investigate the impact of garlic diallyl n-sulfide (Dn-S) on metabolic of quail glycogenolysis pathway. Animal sample were obtained at 11 wk of age ramdomly assigned to five groups of treatment. Each group of treatment involved 5 replicates with 5 quails each (25 laying quails per group). All of the groups were provided basal diet and orally administered with treatements group i.e. group of thermoneutral zone (24°C) without Dn-S; group of heat stress (38°C) without Dn-S; group of heat stress (38°C) and 75 µL of Dn-S; group of heat stress (38°C) and 100 µL of Dn-S; group of heat stress (38°C) and 125 µL of Dn-S. Based on the result in this experiment showed that heat stress contibutes of the increase of glycogenolysis and metabolic compund, also enzime which is catalized its pathway. The Administered of 125 µL of Dn-S decreased glycogenolysis rate, effectivelly. In conclusion, Dn-S plays the main role to avoid exrtacelluler osmotic and metabolism fluctuation related heat stress. 


metabolism; heat stress; diallyl n-sulfide; quail


Al-Haidary A., Spiers, D.E., Rottinghaus, G.E., Garner, G.B., & Ellersieck, M.R. (2001). Thermoregulatory ability of beef heifers following intake of endophyte-infected tall fescue during controlled heat challenge. Journal of Animal Sciemce, 79(1), 1780–1788.

Amin S., Ruswanto, & Negoro, Y.I. (2014). Analisis Minyak Atsiri Umbi Bawang Putih Menggunakan Kromatografi Gas Spektofotometrik Massa. Jurnal Kesehatan Bakti Tunas Husada, 11(1), 37-45.

Antosiewicz, S., Anna, H. A., Stanley, W. M., & Shivendra, V. S. (2006). c-jun NH2-terminal kinase signaling axis regulates diallyl trisulfide-induce generation of reactive oxygen species and cell cycle arrest in human prostate cancer cells. Cancer Research, 66(4), 5379-5386.

Ao, X., Yoo, J. S., Lee, J. H., Jang, H. D., Wang, J. P., Zhou, T. X., & Kim, I. H. (2010). Effects of fermented garlic powder on production performance, egg quality, blood profiles and fatty acids composition of egg yolk in laying hens. Asian-Australasian Journal of Animal Sciences, 23(6), 786-791.

Behera, N. K., Babu, L. K., Sahoo, S. K., Giri, S. C., Pati, P. K., Panigrahi, B., & Joshi, S. K. (2016). Effect of feeding different levels of protein on mortality, carcass characteristics, biochemical parameter, time motion study and economics of Desi Ducks under intensive system of rearing. Asian Journal of Animal Sciences, 10(1), 106-112.

Block, E. (1985). The Chemistry of garlic and oniong. Sci. American, 252(9), 115-119.

Chauhan, S. S., Celi, P., Leury, B. J., Clarke, I. J., & Dunshea, F. R. (2014). Dietary antioxidants at supranutritional doses improve oxidative status and reduce the negative effects of heat stress in sheep. Journal of Animal Science, 92(8), 3364-3374.

Choi, I. H., Park, W. Y., & Kim, Y. J. (2010). Effects of dietary garlic powder and α-tocopherol supplementation on performance, serum cholesterol levels, and meat quality of chicken. Poultry Science, 89(8), 1724-1731.

Dinana, A., Latipudin, D., Darwis, D., & Mushawwir, A. (2019). Profil Enzim Transaminase Ayam Ras Petelur Yang Diberi Kitosan Iradiasi. Jurnal Nutrisi Ternak Tropis dan Ilmu Pakan, 1(1).

Filomeni, G., Aquilano, K., Rotilio, G., & Ciriolo, M. R. (2003). Reactive oxygen species-dependent c-Jun NH2-terminal kinase/c-Jun signaling cascade mediates neuroblastoma cell death induced by diallyl disulfide. Cancer research, 63(18), 5940-5949.

Gomez, K. A., & Gomez, A. A. (1995). Prosedur statistik untuk penelitian pertanian. Edisi ke, 2. Penerbit Universitas Indonesia, Jakarta.

Goncalves, R. L., Quinlan, C. L., Perevoshchikova, I. V., Hey-Mogensen, M., & Brand, M. D. (2015). Sites of superoxide and hydrogen peroxide production by muscle mitochondria assessed ex vivo under conditions mimicking rest and exercise. Journal of Biological Chemistry, 290(1), 209-227.

Howard, J. T., Kachman, S. D., Nielsen, M. K., Mader, T. L., & Spangler, M. L. (2013). The effect of myostatin genotype on body temperature during extreme temperature events. Journal of animal science, 91(7), 3051-3058.

Kim, Y. J., Jin, S. K., & Yang, H. S. (2009). Effect of dietary garlic bulb and husk on the physicochemical properties of chicken meat. Poultry Science, 88(2), 398-405.

Latipudin, D., & Mushawwir, A. (2011). Regulasi panas tubuh ayam ras petelur fase grower dan layer. Jurnal Sain Peternakan Indonesia, 6(2), 77-82.

Lee, D. H., Lim, S. R., Han, J. J., Lee, S. W., Ra, C. S., & Kim, J. D. (2014). Effects of dietary garlic powder on growth, feed utilization and whole body composition changes in fingerling sterlet sturgeon, Acipenser ruthenus. Asian-Australasian journal of animal sciences, 27(9), 1303.

Loyau, T., Métayer-Coustard, S., Berri, C., Crochet, S., Cailleau-Audouin, E., Sannier, M., ... & Couroussé, N. (2014). Thermal manipulation during embryogenesis has long-term effects on muscle and liver metabolism in fast-growing chickens. PLoS One, 9(9).

Ma, X., Lin, Y., Zhang, H., Chen, W., Wang, S., Ruan, D., & Jiang, Z. (2014). Heat stress impairs the nutritional metabolism and reduces the productivity of egg-laying ducks. Animal reproduction science, 145(3-4), 182-190.

Murray, R.K., Bender, D. A., Botham, K.M., Kennelly, P.J., Rodwell, V.W., & Weil, P.A. (2012). Biokimia Harper, edisi 29. EGC Penerbit Buku Kedokteran.

Mushawwir A., & Latipuddin, D. (2013). Biologi Sintesis Telur, perspektif Fisologi, Biokimia dan Molekuler Produksi Telur. Penerbit Graha Ilmu, Yogyakarta.

Mushawwir, A. (2015). Biokimia Nutrisi. Widya Padjadjaran, Bandung.

Mushawwir, A., & Latipudin, D. (2011). Beberapa Parameter Biokimia Darah Ayam Ras Petelur Fase Grower dan Layer dalam Lingkungan “Upper Zonathermoneutral”. Jurnal Peternakan Indonesia (Indonesian Journal of Animal Science), 13(3), 191-198.

Mushawwir, A., & Latipudin, D. (2012). Respon fisiologi thermoregulasi ayam ras petelur fase grower dan layer. Proseding seminar zootechniques for Indogeneous resources development, ISAA Fakultas Petenakan Universitas Diponegoro. In Proceeding of National Seminar on Zootechniques (Vol. 1, pp. 23-27).

Mushawwir, A., Adriani, L., & Kamil, K. A. (2011). Prediction Models for Olfactory Metabolic and Sows% Rnareticulocyt (Rnart) by Measurement of Atmospheric Ammonia Exposure and Microclimate Level. Journal of the Indonesian Tropical Animal Agriculture, 36(1), 14-20.

Mushawwir, A., Suwarno, N., & Yulianti, A. A. (2019). Profil Malondialdehyde (MDA) dan Kreatinin Itik Fase Layer yang Diberi Minyak Atsiri Garlic Dalam Kondisi Cekaman Panas. Jurnal Ilmu dan Industri Peternakan, 5(1), 1-11.

Mushawwir, A., Suwarno, N., & Yulianti, A. A. (2019a). Thermoregulasi domba ekor gemuk yang dipelihara pada ketinggian tempat (Altitude) yang berbeda. Jurnal Ilmu dan Industri Peternakan, 5(2), 77-86.

Mushawwir, A., Tanuwiria, U. H., Kamil, K. A., Adriani, L., & Wiradimadja, R. (2017). Effects of volatile oil of garlic on feed utilization, blood biochemistry and performance of heat-stressed japanese quail. Asian J. Poult. Sci, 11(2), 83-89.

Mushawwir, A., Yong, Y. K., Adriani, L., Hernawan, E., & Kamil, K. A. (2010). The fluctuation effect of atmospheric ammonia (NH3) exposure and microclimate on hereford bulls hematochemical. Journal of the Indonesian Tropical Animal Agriculture, 35(4), 232-238.

Nelson, D. L., Lehninger, A. L., & Cox, M. M. (2008). Lehninger principles of biochemistry. Macmillan.

Olobatoke, R. Y., & Mulugeta, S. D. (2011). Effect of dietary garlic powder on layer performance, fecal bacterial load, and egg quality. Poultry science, 90(3), 665-670.

Oresanya, T. F., Beaulieu, A. D., & Patience, J. F. (2008). Investigations of energy metabolism in weanling barrows: The interaction of dietary energy concentration and daily feed (energy) intake. Journal of animal science, 86(2), 348-363.

Pearce, S. C., Gabler, N. K., Ross, J. W., Escobar, J., Patience, J. F., Rhoads, R. P., & Baumgard, L. H. (2013). The effects of heat stress and plane of nutrition on metabolism in growing pigs. Journal of animal science, 91(5), 2108-2118.

Peinado, M. J., Ruiz, R., Echávarri, A., & Rubio, L. A. (2012). Garlic derivative propyl propane thiosulfonate is effective against broiler enteropathogens in vivo. Poultry Science, 91(9), 2148-2157.

Ramadhina, I. A., Adriani, L., & Sujana, E. (2019). Pengaruh pemberian ekstrak daun kepel (stelechocarpus burahol) terhadap kadar kolesterol darah dan telur puyuh (Coturnix-coturnix japonica). Jurnal Nutrisi Ternak Tropis dan Ilmu Pakan, 1(1), 34-40.

Renaudeau, D., Collin, A., Yahav, S., De Basilio, V., Gourdine, J. L., & Collier, R. J. (2012). Adaptation to hot climate and strategies to alleviate heat stress in livestock production. Animal, 6(5), 707-728.

Roland, L., Drillich, M., Klein-Jöbstl, D., & Iwersen, M. (2016). Invited review: Influence of climatic conditions on the development, performance, and health of calves. Journal of dairy science, 99(4), 2438-2452.

Royer, E., Barbé, F., Guillou, D., Rousselière, Y., & Chevaux, E. (2016). Development of an oxidative stress model in weaned pigs highlighting plasma biomarkers' specificity to stress inducers. Journal of Animal Science, 94(suppl_3), 48-53.

Sadiah, I. N. (2015). Mortalitas embrio dan daya tetas itik lokal (Anas sp.) berdasarkan pola pengaturan temperatur mesin tetas. Students e-Journal, 4(3), 32-39.

Sahara, E., Sandi, S., & Sari, M. L. (2019). Dampak pemberian tepung bawah putih terhadap profil lipid liver dan plasma darah puyuh yang mengalami cekaman panas. Jurnal Nutrisi Ternak Tropis dan Ilmu Pakan, 1(1), 16-24.

Shinder, D., Rusal, M., Tanny, J., Druyan, S., & Yahav, S. (2007). Thermoregulatory responses of chicks (Gallus domesticus) to low ambient temperatures at an early age. Poultry science, 86(10), 2200-2209.

Slimen, B.I., Najar, T., Ghram, A., & Abdrrabba, M. (2016). Heat stress effects on livestock: molecular, cellular and metabolic aspects, a review. Journal of Animal Physiology and Animal Nutrition, 100(3), 401-412.

Suwarno, N., & Mushawwir, A. (2019). Model Prediksi Metabolit Melalui Jalur Glikogenolisis Berdasarkan Fluktuasi Mikroklimat Lingkungan Kandang Sapi Perah. Jurnal Ilmu dan Industri Peternakan, 5(2), 97-107.

Tao, S., & Dahl, G. E. (2013). Invited review: heat stress effects during late gestation on dry cows and their calves. Journal of dairy science, 96(7), 4079-4093.

Won, S., Xie, G., Boddicker, R., Rhoades, J., Scheffler, T., Scheffler, J., ... & Baumgard, L. (2012). Acute duration heat stress alters expression of cellular bioenergetic-associated genes in skeletal muscle of growing pigs. J. Anim. Sci, 95, 573.

Yang, C. S., Chhabra, S. K., Hong, J. Y., & Smith, T. J. (2001). Mechanisms of inhibition of chemical toxicity and carcinogenesis by diallyl sulfide (DAS) and related compounds from garlic. The Journal of nutrition, 131(3), 1041S-1045S.


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